Publications

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils

bioRxiv [Preprint]. 2024 Apr 15:2024.04.11.589146. PMID: 38659904

Huynh TN, Toperzer J, Scherer A, Gumina A, Brunetti T, Mansour MK, Markovitz DM, Russo BC.

Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators

bioRxiv [Preprint]. 2024 Mar 4:2024.02.29.582846. PMID: 38496490

Bonilla G, Morris A, Kundu S, Ducasse A, Jeffries NE, Chetal K, Yvanovich EE, Barghout R, Scadden D, Mansour MK, Kingston RE, Sykes DB, Mercier FE, Sadreyev RI.

Third-party fecal microbiota transplantation for high-risk treatment-naïve acute GVHD of the lower GI tract

Blood Adv. 2024 Mar 12:bloodadvances.2024012556. PMID: 38471063

DeFilipp Z, Damania AV, Kim HT, Chia-Chi C, El-Jawahri A, McAfee SL, Bottoms AS, Toncheva V, Smith MM, Dolaher M, Perry LS, White M, Diana B, Connolly S, Dey BR, Frigault MJ, Newcomb RA, O’Donnell PV, Spitzer TR, Mansour MK, Weber D, Ajami NJ, Hohmann E, Jenq RR, Chen YB.

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming

bioRxiv. 2023 Jun 28;2023.06.27.546744. PMID: 37425711

Strickland J, Pan D, Godfrey C, Kim JS, Hopke A, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner OD.

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Blood. 2023 Aug 17;142(7):658-674. PMID: 37267513

Rhee C, Scadden EW, Wong LP, Schiroli G, Mazzola MC, Chea PL, Kato H, Hoyer FF, Mistry M, Lee BK, Kim J, Nahrendorf M, Mansour MK, Sykes DB, Sadreyev RI, Scadden DT.

Multiparametric Profiling of Neutrophil Function via a High-Throughput Flow Cytometry-Based Assay

Cells. 2023 Feb 25;12(5):743. PMID: 36899878

Timmer KD, Floyd DJ, Scherer AK, Crossen AJ, Atallah J, Viens AL, Sykes DB, Mansour MK.

Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi

iScience . 2022 Sep 28;25(10):105226. PMID: 36267914

Hopke A, Lin T, Scherer AK, Shay AE, Timmer KD, Wilson-Mifsud B, Mansour MK, Serhan CN, Irimia D, Hurley BP.

Photoinactivation of Catalase Sensitizes Candida albicans and Candida auris to ROS-Producing Agents and Immune Cells

Adv Sci (Weinh) . 2022 Apr;9(10):e2104384. PMID: 35119220

Dong PT, Zhan Y, Jusuf S, Hui J, Dagher Z, Mansour MK, Cheng JX.

Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood

Lab Chip . 2022 Mar 1;22(5):936-944. PMID: 35084421

Sakuma M, Wang X, Ellett F, Edd JF, Babatunde KA, Viens A, Mansour MK, Irimia D.

Host-informed therapies for the treatment of pneumococcal pneumonia.

Trends Mol Med. 2021 Aug 7:S1471-4914(21)00189-1. Online ahead of print. PMID: 34376327

Sundaresh B, Xu S, Noonan B, Mansour MK, Leong JM, van Opijnen T

Immunomodulation as Treatment for Severe COVID-19: a systematic review of current modalities and future directions

Clin Infect Dis. 2020 Nov 20; ciaa1759. Online ahead of print. PMID: 33216852

Eric A Meyerowitz, Pritha Sen, Sara R Schoenfeld, Tomas G Neilan, Matthew J Frigault, John H Stone, Arthur Y Kim, Michael K Mansour, CIG (COVID-19 Immunomodulatory Group)

Management of immunotherapy colitis: Special considerations in the COVID-19 era

Cancer. 2020 Nov 1;126(21):4630-4633. Epub 2020 Aug 14. PMID: 32797685

Shilpa Grover, Sheila A Bond, Michael K Mansour, Sonia Friedman

CD82 controls CpG-dependent TLR9 signaling.

FASEB J. 2019 Aug 13. PMID: 31408613

Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz Z, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, ArtavanisTsakonas K, Frickel E, Becker C, Dagher Z, Kim Y, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM

Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.

J Immunol. 2019 Apr 22.

Selective Hematopoietic Stem Cell (HSC) Ablation using CD117 Antibody-Drug-Conjugates Enables Safe and Effective HSC Transplantation with Preservation of Immunity.

Nature Communications. 2019 Feb 6;10(1):617

Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Walck E, Sykes DB, Shizuru JA, Winau F, Scadden DT, Rossi DJ

It takes a village: phagocytes play a central role in fungal immunity.

Semin Cell Dev Biol. 2018 May 14. PMID: 29727727

Feldman MB, Vyas JM, Mansour MK

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

PLoS Pathog. 2018 May 21;14(5):e1007073. PMID: 29592876. PMCID: PMC5983859

Fites SJ, Gui M, Negoro P, Dagher Z, Sykes DB, Mansour MK, Klein BS

Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida.

Nature Communications. 2018 Feb 21;9(1):751. PMID: 29467448. PMCID: PMC5821813

. Li SS, Ogbomo H, Mansour MK, Xiang RF, Szabo L, Munro F, Mukherjee P, Mariuzza RA, Amrein M, Vyas JM, Robbins SM, Mody CH

The Carbohydrate Lectin Receptor, Dectin-1, Mediates Immune Response to Exserohilum rostratum.

Infect Immun. 2017 Feb 23;85(3). pii: e00903-16. PMID: 28031265. PMCID: PMC5328484

Reedy JL, Negoro PE, Feliu M, Lord AK, Khan NS, Lukason DP, Wiederhold NP, Tam JM, Mansour MK, Patterson TF, Vyas JM

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Nature Biotechnol. 2016 Jun 6. PMID: 27272386. PMCID: PMC5179034

F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT

The Role of Autophagy-Related Proteins in Candida albicans Infections.

Pathogens. 2016 Mar 29;5(2). pii: E34. PMID: 27043636. PMCID: PMC4931385

Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM

PKC-δ activation in neutrophils promotes fungal clearance.

J Leukoc Biol. 2016 Mar 10. pii: jlb.4A0915-405R. PMID: 26965632. PMCID in process

Li X, Cullere X, Nishi H, Saggu G, Durand E, Mansour MK, Tam JM, Song XY, Lin X, Vyas JM, Mayadas T

Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan.

J Immunol. 2016 Mar 1;196(5):2249-61. PMID: 26829985. PMCID: PMC4761466

Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM

Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes.

Med Microbiol Immunol. 2014 Dec;203(6):415-24. PMID: 25129478. PMCID: PMC4232755

Klassert TE, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H

Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

J Infect Dis. 2014 Dec 1;210(11):1844-54. PMID: 24842831. PMCID: PMC4271056

Tam J, Mansour MK, Khan N, Seward M, Purnam S, Tanne A, Sokolovska A, Becker C, Acharya M, Baird M, Davidson M, Segal B, Lacy-Hulbert A, Stuart L, Xavier R, Vyas JM

Identification of Candida glabrata Genes Involved in pH Modulation and Modification of the Phagosomal Environment in Macrophages.

PLoS One. 2014 May 1;9(5):e96015. 2014. PMID: 24789333. PMCID: PMC4006850

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B

Macrophage-Cryptococcus Interactions: An Update.

2013 Dec. Curr Fungal Infect Rep. 2014 Mar 1;8(1):109-115. PMID:24660045. PMCID: PMC3958962

Mansour MK, Reedy JR, Tam JM, Vyas JM

Dectin-1 activation controls maturation of β-1,3-glucan-containing phagosomes.

J. Biol. Chem. 2013 May 31;288(22):16043– 16054. PMID: 23609446. PMCID: PMC3668760

Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, and Vyas JM

Monocyte and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.

J Immunol. 2013 Apr 15;190(8):4175-84. PMID: 23509361. PMCID: PMC3622122

Grimm, MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan ANH, D’Auria1 A, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH

The Cell Biology of the Innate Immune Response to Aspergillus fumigatus.

Annals of the New York Academy of Sciences. 2012. Dec;1273(1):78-84. PMID: 23230841. PMCID: PMC3531818

Mansour MK, Tam JM, Vyas JM

Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immunity.

Integr Biol. 2012 Feb;4(2):220-227. PMID: 22200052. PMCID: PMC3346694

Tam JM* and Mansour MK*, Khan NS, Yoder N and Vyas JM * = co-first authors.

Dynamic Virulence: Real-time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome.

MBio. 2011 Sep 27;2(5). pii: e00217-11. PMID: 21954307

Mansour MK, Vyas JM, and Levitz SM

Toll-like receptor 9 modulates macrophage antifungal effector function during innate recognition of C. albicans and S. cerevisiae.

Infect Immun. 2011 Dec;79(12):4858-4867. PMID: 21947771. PMCID: PMC3232661

Kasperkovitz PV, Khan NS, Tam JT, Mansour MK, Davids PJ, and Vyas JM

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.

J Vis Exp. 2011 Jul 28;(53). pii: 3123. PMID: 21841755. PMCID: PMC3197446

Tam JM, Castro CE, Heath RJW, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, and Vyas JM

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Cryptococcus neoformans Mannoprotein are captured by multiple lectin receptors and exclusively presented by dendritic cells.

J Immunol. 2006 Mar 1;176(5):3053-3061. PMID: 16493064

Mansour MK, Latz E, and Levitz SM

A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity.

J Immunol. 2005 Dec 1;175(11):7496-7503. PMID: 16301657

Lam J, Mansour MK, Specht C, and Levitz SM

Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo.

Infect Immun. 2005 Dec;73(12):8429-8432. PMID: 16299344. PMCID: PMC1307074

Yauch L, Mansour MK, and Levitz SM

Involvement of CD14, Tolllike Receptor (TLR) 2, TLR 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo.

Infect Immun. 2004 Sep;72(9):5373-5382. PMID: 15322035. PMCID: PMC517466

Yauch L, Mansour MK, Shoham S, Rottman JB, and Levitz SM

Protective efficacy of antigenic fractions in mouse models of cryptococcosis.

Infect Immun. 2004 Mar;72(3):1746-1754. PMID: 14977983. PMCID: PMC356047

Mansour MK, Yauch L, Rottman JB, and Levitz SM

Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T cell responses.

Infect Immun. 2002 Oct;70(10):5485-5493. PMID: 12228274. PMCID: PMC128329

Huang C, Nong SH, Mansour MK, Specht CA, and Levitz SM

Optimal T-cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors.

J Immunol. 2002 Mar 15;168(6):2872-2879. PMID: 11884457

Mansour MK, Schelsinger LS, and Levitz SM

Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10422-10427. PMID: 11504924. PMCID: PMC56976

Levitz SM, Nong S, Mansour MK, Huang C, and Specht CA

Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1.

Am J Pathol. 1996 Mar;148(3):855-864. PMID: 8774140. PMCID: PMC1861724

Rand ML, Warren JS, Mansour MK, Newman W, and Ringler DJ

novel host response-based diagnostics to differentiate the etiology of fever in patients presenting to the emergency department

Diagnostics (Basel). 2023 Mar 2;13(5):953. PMID: 36900096

Atallah J, Ghebremichael M, Timmer KD, Warren HM, Mallinger E, Wallace E, Strouts FR, Persing DH, Mansour MK

Impact of adherence to procalcitonin antibiotic prescribing guideline recommendations for low procalcitonin levels on antibiotic use

BMC Infect Dis . 2023 Jan 19;23(1):30. PMID: 36658543

Malley BE, Yabes JG, Gimbel E, Chang CH, Yealy DM, Fine MJ, Angus DC, Huang DT; ProACT Investigators.

Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19

Blood. 2022 Nov 3;140(18):1993-1997. PMID: 36096050

Miller PG, Fell GG, Foy BH, Scherer AK, Gibson CJ, Sperling AS, Burugula BB, Nakao T, Uddin MM, Warren H, Bry L, Pozdnyakova O, Frigault MJ, Bick AG, Neuberg D, Higgins JM, Mansour MK, Natarajan P, Kim AS, Kitzman JO, Ebert BL.

Mid-regional Proadrenomedullin Biomarker Predicts Coronavirus Disease 2019 Clinical Outcomes: A US-Based Cohort Study

Open Forum Infect Dis. 2022 Aug 24;9(9):ofac423. PMID: 36072696

Atallah NJ, Panossian VS, Atallah CJ, Schwabe A, Johannes S, Wiemer J, Mansour MK.

Rapid Quantum Magnetic IL-6 Point-of-Care Assay in Patients Hospitalized with COVID-19

Diagnostics (Basel). 2022 May 7;12(5):1164. PMID: 35626318

Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in COVID-19: A case-control study

PLoS One. 2022 Jan 13;17(1):e0262342. PMID: 35025929

Atallah NJ, Warren HM, Roberts MB, Elshaboury RH, Bidell MR, Gandhi RG, Adamsick M, Ibrahim MK, Sood R, Bou Zein Eddine S, Cobler-Lichter MJ, Alexander NJ, Timmer KD, Atallah CJ, Viens AL, Panossian VS, Scherer AK, Proctor T, Smartt S, Letourneau AR, Paras ML, Johannes S, Wiemer J, Mansour MK.

Cytokine Augmentation Reverses Transplant Recipient Neutrophil Dysfunction Against the Human Fungal Pathogen Candida albicans.

J Infect Dis. 2021 Sep 1;224(5):894-902. PMID: 33417688

Barros N, Alexander N, Viens A, Timmer K, Atallah N, Knooihuizen SAI, Hopke A, Scherer A, Dagher Z, Irimia D, Mansour MK.

Incidence, Predictors, and Outcomes of Thrombotic Events in Hospitalized Patients With Viral Pneumonia.

Am J Cardiol. 2021 Mar 15;143:164-165. Epub 2021 Jan 14.PMID: 33453170

Elgendy IY, Kolte D, Mansour MK, Sakhuja R, Elmariah S, Jaffer FA, Neilan TG, Januzzi JL, Weinberg I, Albaghdadi MS.

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

JAMA. 2021 Aug 10;326(6):499-518. PMID: 34228774

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Shankar-Hari M, Vale CL, Godolphin PJ, Fisher D, Higgins JPT, Spiga F, Savovic J, Tierney J, Baron G, Benbenishty JS, Berry LR, Broman N, Cavalcanti AB, Colman R, De Buyser SL, Derde LPG, Domingo P, Omar SF, Fernandez-Cruz A, Feuth T, Garcia F, Garcia-Vicuna R, Gonzalez-Alvaro I, Gordon AC, Haynes R, Hermine O, Horby PW, Horick NK, Kumar K, Lambrecht BN, Landray MJ, Leal L, Lederer DJ, Lorenzi E, Mariette X, Merchante N, Misnan NA, Mohan SV, Nivens MC, Oksi J, Perez-Molina JA, Pizov R, Porcher R, Postma S, Rajasuriar R, Ramanan AV, Ravaud P, Reid PD, Rutgers A, Sancho-Lopez A, Seto TB, Sivapalasingam S, Soin AS, Staplin N, Stone JH, Strohbehn GW, Sunden-Cullberg J, Torre-Cisneros J, Tsai LW, van Hoogstraten H, van Meerten T, Veiga VC, Westerweel PE, Murthy S, Diaz JV, Marshall JC, Sterne JAC.

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

N Engl J Med. 2020 Dec 10; 383(24):2333-2344. Epub 2020 Oct 21. PMID: 33085857

John H Stone 1, Matthew J Frigault 1, Naomi J Serling-Boyd 1, Ana D Fernandes 1, Liam Harvey 1, Andrea S Foulkes 1, Nora K Horick 1, Brian C Healy 1, Ruta Shah 1, Ana Maria Bensaci 1, Ann E Woolley 1, Sarah Nikiforow 1, Nina Lin 1, Manish Sagar 1, Harry Schrager 1, David S Huckins 1, Matthew Axelrod 1, Michael D Pincus 1, Jorge Fleisher 1, Chana A Sacks 1, Michael Dougan 1, Crystal M North 1, Yuan-Di Halvorsen 1, Tara K Thurber 1, Zeina Dagher 1, Allison Scherer 1, Rachel S Wallwork 1, Arthur Y Kim 1, Sara Schoenfeld 1, Pritha Sen 1, Tomas G Neilan 1, Cory A Perugino 1, Sebastian H Unizony 1, Deborah S Collier 1, Mark A Matza 1, Janeth M Yinh 1, Kathryn A Bowman 1, Eric Meyerowitz 1, Amna Zafar 1, Zsofia D Drobni 1, Marcy B Bolster 1, Minna Kohler 1, Kristin M D’Silva 1, Jonathan Dau 1, Megan M Lockwood 1, Caroline Cubbison 1, Brittany N Weber 1, Michael K Mansour 1, BACC Bay Tocilizumab Trial Investigators

PCT-guided antibiotic stewardship versus usual care for hospitalized patients with suspected sepsis or lower respiratory tract infections in the US: a model-based cost analysis.

PLoS One. 2019 Apr

Mewes JC, Pulia MS, Mansour MK, Broyles MR, Nguyen BH, Steuten LMG

Pharmacokinetic analysis of isavuconazole administered by NG tube.

Transplant Infectious Diseases. 2019 Jan 13:e13048. PMID:30636363

Gandhi R, Mansour MK, Elshaboury R

Malakoplakia in Thoracic Transplant Recipients: case reports and review of the literature.

Transplant Proc. Apr;51(3):871-874. 2019 Jan 8. PMID: 30979478

Lane RJ, Kradin R, Xia D, Buchan CA, Turbett S, Kotton CN, Mansour MK

The Great Opportunity: Cultivating Scientific Inquiry in Medical Residency.

J Infect Dis. 2018 Jun 7. PMID: 29878132

Vyas JM, Rajagopal J, Sokol CL, Wein MN, Mansour MK, Corey KE, Fishman MC, Armstrong KA

Third-party fecal microbiota transplantation following allogeneic hematopoietic cell transplantation reconstitutes microbiome diversity.

Blood Adv. 2018 Apr 10;2(7):745-753. PMID: 29592876

Zachariah DeFilipp Z, Peled JU, Li S, Mahabamunuge J, Dagher Z, Slingerland AE, Del Rio C, Valles B, Kempner ME, Smith M, Brown J, Dey BR, El-Jawahri A, McAfee SL, Spitzer TR, Ballen KK, Sung AD, Dettmer K, Liebisch G, Oefner P, Taur Y, Pamer EG, Holler E, Mansour MK, van den Brink MR, Hohmann E, Jenq RR, Chen YB

Cervical Lymphatic Filariasis in a Pediatric Patient: Case Report and Database Analysis of Lymphatic Filariasis in the United States.

The American Journal of Tropical Medicine and Hygiene. 2018 May 29. PMID: 29848402

Simmonds, J, Mansour, MK, Dagher, W

Serial Procalcitonin as a Predictor of Bacteremia and Need for Intensive Care Unit Care in Adults with Pneumonia, Including Those With Highest Severity: A Prospective Cohort Study.

Open Forum Infect Dis. 2017 Jan 4;4(1). PMID: 28480236. PMCID: PMC5414101

McCluskey SM, Schuetz P, Abers MS, Bearnot B, Morales ME, Hoffman D, Patel S, Rosario L, Chiappa V, Parry BA, Callahan RT, Bond SA, Lewandrowski K, Binder W, Filbin MR, Vyas JM, Mansour MK

Personalized Medicine: is it time for Infectious Diseases?

Saudi Med J. 2016 Dec;37(12):1309-1311. PMID: 27874145. PMCID: PMC5303767

Al-Mozaini, M, Mansour MK

HIV-Care Outcome in Saudi Arabia; a Longitudinal Cohort.

J AIDS Clin Res. 2014 Nov 8;5(11):370.

Maha A Al-Mozaini, Salmaan Keshavjee, Fadi F Masharqa, Abdullah A Al-Hokail, Magid A Mohmed, Munirah A Bin Daham, Hail M Al-Abdely, Husn H Frayha, Fahad A Al-Rabiah, Sami H Alhajjar, Chaker N Adra, Mansour MK, Abdulrahman A. Alrajhi

Promising New Assays and Technologies for the Diagnosis and Management of Infectious Diseases.

Clin Infect Dis. 2013 Apr;56(7):996-1002. PMID: 23223587. PMCID: PMC3657496

Mitsuma SF*, Mansour MK*, Dekker JP, Kim J, Rahman MZ, Tweed-Kent A, Schuetz P

* = co-first authors.

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

mBio. 2024 Apr 10;15(4):e0007224. PMID: 38501869

Arastehfar A, Daneshnia F, Floyd DJ, Jeffries NE, Salehi M, Perlin DS, Ilkit M, Lass-Flöerl C, Mansour MK

Evaluation of outbreak persistence caused by multidrug-resistant and echinocandin-resistant Candida parapsilosis using multidimensional experimental and epidemiological approaches

Emerg Microbes Infect. 2024 Dec;13(1):2322655. PMID: 38380673

Daneshnia F, Floyd DJ, Ryan AP, Ghahfarokhy PM, Ebadati A, Jusuf S, Munoz J, Jeffries NE, Elizabeth Yvanovich E, Apostolopoulou A, Perry AM, Lass-Flörl C, Birinci A, Hilmioğlu-Polat S, Ilkit M, Butler G, Nobile CJ, Arastehfar A, Mansour MK

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

Nat Microbiol. 2024 Jan;9(1):95-107. PMID: 38168615

Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA, Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM.

Invasive fungal infections in liver diseases

Hepatol Commun. 2023 Aug 28;7(9):e0216. PMID: 37639701

Barros N, Rosenblatt RE, Phipps MM, Fomin V, Mansour MK

Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance

Int J Antimicrob Agents. 2023 Jul;62(1):106831. PMID: 37121442

Daneshnia F, Arastehfar A, Lombardi L, Binder U, Scheler J, Vahedi Shahandashti R, Hagen F, Lass-Flörl C, Mansour MK, Butler G, Perlin DS.

Whole-genome sequencing confirms a persistent candidaemia clonal outbreak due to multidrug-resistant Candida parapsilosis

J Antimicrob Chemother. 2023 Jun 1;78(6):1488-1494. PMID: 37100456

Daneshnia F, Hilmioğlu-Polat S, Ilkit M, Fuentes D, Lombardi L, Binder U, Scheler J, Hagen F, Mansour MK, Butler G, Lass-Flörl C, Gabaldon T, Arastehfar A.

The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan

mBio. 2023 Feb 28;14(1):e0318422. PMID: 36598192

Reedy JL, Crossen AJ, Negoro PE, Harding HB, Ward RA, Vargas-Blanco DA, Timmer KD, Reardon CM, Basham KJ, Mansour MK, Wüthrich M, Fontaine T, Latgé JP, Vyas JM.

Blue Light Deactivation of Catalase Suppresses Candida Hyphae Development Through Lipogenesis Inhibition

Photochem Photobiol. 2022 Sep 19. Online ahead of print. PMID: 36117418

Jusuf S, Zhan Y, Zhang M, Alexander NJ, Viens A, Mansour MK, Cheng JX.

Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections

J Leukoc Biol. 2022 Jun;111(6):1133-1145. PMID: 35355310

Sykes DB, Martinelli MM, Negoro P, Xu S, Maxcy K, Timmer K, Viens AL, Alexander NJ, Atallah J, Snarr BD, Baistrocchi SR, Atallah NJ, Hopke A, Scherer A, Rosales I, Irimia D, Sheppard DC, Mansour MK.

TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils

J Immunol . 2022 Apr 1;208(7):1664-1674. PMID: 35277418

Viens AL, Timmer KD, Alexander NJ, Barghout R, Milosevic J, Hopke A, Atallah NJ, Scherer AK, Sykes DB, Irimia D, Mansour MK.

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Cell Stem Cell. 2021 Dec 2;28(12):2090-2103.e9. PMID: 34551362

Kfoury YS, Ji F, Mazzola M, Sykes DB, Scherer AK, Anselmo A, Akiyama Y, Mercier F, Severe N, Kokkaliaris KD, Zhao T, Brouse T, Saez B, Seidl J, Papazian A, Ivanov P, Mansour MK, Sadreyev RI, Scadden DT.

POLARIZATION-SENSITIVE STIMULATED RAMAN SCATTERING IMAGING RESOLVES AMPHOTERICIN B ORIENTATION IN CANDIDA MEMBRANE.

Sci Adv. 2021 Jan 6;7(2):eabd5230. Print 2021 Jan.PMID: 33523971

Dong PT, Zong C, Dagher Z, Hui J, Li J, Zhan Y, Zhang M, Mansour MK, Cheng JX.

Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis.

Hepatol Commun. 2021 Jan 5;5(3):502-515. eCollection 2021 Mar.PMID: 33681682

Knooihuizen SAI, Alexander NJ, Hopke A, Barros N, Viens A, Scherer A, Atallah NJ, Dagher Z, Irimia D, Chung RT, Mansour MK.

The Known Unknowns of the Immune Response to Coccidioides.

J Fungi (Basel). 2021 May 11;7(5):377. PMID: 34065016

Ward RA, Thompson GR 3rd, Villani AC, Li B, Mansour MK, Wuethrich M, Tam JM, Klein BS, Vyas JM.

Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?

PLoS Pathog. 2021 Jul 29;17(7):e1009691. eCollection 2021 Jul.PMID: 34324592

Scherer AK, Hopke A, Sykes DB, Irimia D, Mansour MK.

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.

iScience. 2021 Jul 16;24(8):102871. eCollection 2021 Aug 20.PMID: 34386732

Nguyen GT, Xu S, Adams W, Leong JM, Bunnell SC, Mansour MK, Sykes DB, Mecsas J.

Neutrophil functional profiling and cytokine augmentation for patients with multiple recurrent infections: A case study

J Allergy Clin Immunol Pract 2020 Aug 24;S2213-2198(20)30840-0. Online ahead of print. PMID: 32853820

Natalie J Alexander 1, David J Bozym 2, Joceyln R Farmer 3, Priscilla Parris 2, Adam Viens 1, Natalie Atallah 4, Alex Hopke 5, Allison Scherer 4, Zeina Dagher 4, Nicolas Barros 6, Sally A I Knooihuizen 2, Rebecca R Saff 3, Mark S Pasternack 7, Ryan W Thompson 2, Daniel Irimia 5, Michael K Mansour 8

Candida albicans necrotizing fasciitis following elective surgery

Med Mycol Case Rep. 2020 Apr 20;28:39-41. eCollection 2020 Jun. PMID: 32420013

Natalie J Atallah 1, Allison K Scherer 1, Natalie J Alexander 1, Zeina Dagher 1, Adam L Viens 1, Maged Muhammed 2 3, John A Branda 4 5, Michael K Mansour

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

mBio. 2020 May 12;11(3):e02043-19. 02043-19 PMID: 3239831

Paige E Negoro # 1, Shuying Xu # 1, Zeina Dagher 1, Alex Hopke 2 3, Jennifer L Reedy 1 3, Michael B Feldman 4 3, Nida S Khan 1 3, Adam L Viens 1, Natalie J Alexander 1, Natalie J Atallah 1, Allison K Scherer 1 3, Richard A Dutko 1, Jane Jeffery 1, John F Kernien 5, J Scott Fites 6, Jeniel E Nett 7 5, Bruce S Klein 7 6 5, Jatin M Vyas 1 3, Daniel Irimia 2 3, David B Sykes 8 3, Michael K Mansour

Neutrophil swarming delays the growth of clusters of pathogenic fungi

Nat Commun. 2020 Apr 27;11(1):2031. PMID: 32341348

Employing enzymatic treatment options in the clearance of ocular biofilm-based infections.

J Leukoc Biol. 2019 Jan 28. PMID:30690787

Kugadas A, Geddes-McAlister J, Sykes DB, Mansour MK, Gadjeva M

Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere.

2018 Oct 31;3(5). pii: e00539-18. PMID: 30381356

Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS, Uppuluri P

Biguanides enhance antifungal activity against Candida glabrata.

Virulence. 2018 Jul 2. PMID: 29962263

Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Tam JM, Soukas AA, Sykes DB, Mansour MK

Fluorescent tracking of yeast division clarifies the essential role of Syk in intracellular control of Candida glabrata in macrophages.

Front Immunol. 2018 May

Dagher, Z, Xu, S, Negoro, P, Khan, NS, Feldman, MB, Reedy, JL, Tam, JM, Sykes, DB, Mansour, MK

KRE5 gene null mutant strains of Candida albicans are avirulent and have altered cell wall composition and hypha formation properties.

Eukaryot Cell. 2004 Dec;3(6):1423-1432. PMID: 15590817. PMCID: PMC539026

Herrero A, Megnelli P, Mansour MK, Levitz SM, Bussey H, and Abeijon C

Case 7-2023: A 70-Year-Old Man with Covid-19, Respiratory Failure, and Rashes

N Engl J Med. 2023 Mar 9;388(10):926-937. PMID: 36884326

Mansour MK, King JD, Chen ST, Fishman JA, Nazarian RM.

A Case Report of Fatal Mucormycosis in a 30-Year-Old Patient with Autoimmune Polyendocrine Syndrome Type 1

J Clin Immunol . 2022 May;42(4):863-865. PMID: 35141820

Rosenberg JM, Villalba JA, Ferrè EMN, Mansour MK, Lionakis MS.

Isolated Cerebral Mucormycosis in Immunocompetent Adults who Inject Drugs: Case Reports and Systematic Review of the Literature.

Open Forum Infect Dis. 2020 Nov 13;7(12):ofaa552. eCollection 2020 Dec.PMID: 33409328

Meyerowitz EA, Sanchez S, Mansour MK, Triant VA, Goldberg MB.

Case 31-2020: A 48-Year-Old Man with Lymphoma and Abdominal Pain

N Engl J Med. 2020 Oct 8;383(15):1469-1477. PMID: 33027573

Michael K Mansour 1, Olivia C Smibert 1, Avinash Kambadakone 1, Maroun M Sfeir 1

Case 16-2020: A 47-Year-Old Woman with Recurrent Melanoma and Pulmonary Nodules

N Engl J Med. 2020 May 21;382(21):2034-2043. PMID: 32433841

Katrina A Armstrong 1, Justine V Cohen 1, Jo-Anne O Shepard 1, Erik E Folch 1, Michael K Mansour 1, Jonathan A Stefely

Case 9-2020: A 64-Year-Old Man with Shortness of Breath, Cough, and Hypoxemia

N Engl J Med. 2020 Mar 19;382(12):1150-1159. PMID: 32187473

Kerry L Reynolds 1, Ryan J Sullivan 1, Florian J Fintelmann 1, Michael K Mansour 1, Jonathan England

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

N Engl J Med. 2019 Nov 21;381(21):2043-2050. Epub 2019 Oct 30. PMID: 31665575

Zachariah DeFilipp 1, Patricia P Bloom 1, Mariam Torres Soto 1, Michael K Mansour 1, Mohamad R A Sater 1, Miriam H Huntley 1, Sarah Turbett 1, Raymond T Chung 1, Yi-Bin Chen 1, Elizabeth L Hohmann

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 32-2015. A 57-Year-Old Man with Severe Pneumonia and Hypoxemic Respiratory Failure.

N Engl J Med. 2015 Oct 15;373(16):1554-64. PMID: 26465989

Mansour MK, Ackman JB, Branda JA, Kradin RL

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. A 27-Year-Old Woman with Anemia, Thrombocytosis and Skin Lesions After Travel Abroad.

N Engl J Med. 2017 May 18;376(20):1973-1981. PMID: 28514603

Mansour MK, Foreman, Letourneau, Fintelman, Wallace

Clinical

Fecal ESBL screening: Are we ready for this information?

Clin Infect Dis. 2016 May 3. pii: ciw288. PMID: 27143673. PMCID: PMC4946017

Turbett SE, Mansour MK

Extra-pulmonary applications of procalcitonin: an updated literature review

Expert Rev Mol Diagn . 2022 May;22(5):537-544. doi: 10.1080/14737159.2022.2094705. PMID 35757858

Atallah CJ, Panossian VS, Atallah NJ, Roberts MB, Mansour MK.

Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease

Open Forum Infect Dis. 2021 Sep 25;8(11):ofab483. doi: 10.1093/ofid/ofab483. PMID 34805429

Ward RA, Aghaeepour N, Bhattacharyya RP, Clish CB, Gaudillière B, Hacohen N, Mansour MK, Mudd PA, Pasupneti S, Presti RM, Rhee EP, Sen P, Spec A, Tam JM, Villani AC, Woolley AE, Hsu JL, Vyas JM.

Tocilizumab not associated with increased infection risk after CAR T-cell Therapy: implications for COVID-19

Blood. 2020 Jul 2;136(1):137-139. doi: 10.1182/blood.2020006216. PMID 32457999

Matthew J Frigault 1, Sarah Nikiforow 2, Michael K Mansour 3, Zhen-Huan Hu 4, Mary M Horowitz 4 5, Marcie L Riches 6, Peiman Hematti 7, Cameron J Turtle 8, Mei-Jie Zhang 4, Miguel-Angel Perales 9, Marcelo C Pasquini

Immune Response

Fungal Mannoprotein: The Sweet Path to Immunodominance.

ASM NEWS. 2003 Dec;69(12):595-600

Mansour MK and Levitz SM